Stem cell-derived conditioned medium has also been used in regenerative therapies such wound healing, burn wound, and eye drops in animals. During the growth of stem cells, growth factors are released such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), hepatocyte growth factor (HGF), and transforming growth factor (TGF-β1). It has been demonstrated that conditioned media from adipose-derived stem cells (ADSCs) enhances collagen synthesis, proliferation of keratinocytes, and migration of dermal fibroblasts.
Proteins such as collagen extracted from the stem cell media can do the following functions: (1) enhance tissue engineering and repair, (2) promote apoptosis of damaged cells, (3) repair and replenish extracellular matrix. Overall, proteins extracted from stem cell media provide regenerative function to cells they are exposed to. Indications for commercial regenerative serum range from corneal ulcer, wounds (surgical, fracture, open wound, muscle wound), and dermal lesions.
Our Tide Motion bioreactors provide the capability for easier harvest of the conditioned media as the stem cells adhere to macrocarriers, hence, media is cell-free which can be further purified into cosmeceuticals.