There are many different types of bioreactors available in the market today and choosing the right bioreactor system for cells is crucial for cell culture success. The choice of bioreactor system to use highly depend on the type of cells to be produced, the desired product, the process of the cell culture, and the product density. Esco VacciXcell offers different types of bioreactors, suited for different types of cells, applications, and scales.
This type of bioreactor is specific for adherent cells to culture them in an extremely low shear stress environment. The proprietary “Tide Motion” principle is comparable to the gentle upward and downward movement of the culture medium in the vessel. The alternate exposure provides sufficient nutrient and oxygen consumption during cell culture. As adherent cells are surface dependent, these cells can attach to a robust geometrically designed macroporous carrier to mimic its in vivo state as it grows.
CelXrocker is used for process optimization in using 3D macroporous carriers in T-flasks. The rocker provides gentle side-to-side rocking motion for mixing in culture, flasks, tubes, and dishes. The rocker is designed to conveniently fit in most CO2 incubators and refrigerators; thereby, set-up or assay can be placed in a controlled environment.
The CelCradle X is a single-use, closed, automated bioreactor based on the Tide Motion platform. It is a standalone unit manufactured in an ISO 13485 Esco factory and complies with cGMP requirements of 21 CFR part 11. This system is best used for cell cultures involving autologous therapy applications as it is equipped with its own harvesting system.
The CelCradle system is a bench-scale, disposable bioreactor capable of high-density cell culture for protein expression, virus, and monoclonal antibody production. It is designed based on the concept of the bellow-induced intermittent flow of culture medium and air through macroporous matrices, where cells reside.
TideXcell bioreactor system is the extended large-scale system of the laboratory scale CelCradle® bioreactor system. In this system, the matrix vessel and the mixing vessel are separated to aid in the 100% medium exchange requirements of the user. It is also a combination technology equipped with its own harvester for high product yield after every culture.
This type of bioreactor is commonly used for fermentation or microbial culture applications. It adapts the same, conventional stirring method for culture and has different fluid dynamics for agitation. This agitation is done through impellers that have different designs to cater high oxygen transfer during cell culture.
StirCradle is a desk-type bioreactor or fermenter for microorganism cell culture. By combining the vessel, workbench, controller, and peristaltic pumps into one integrated system, this patented stirred-tank bioreactor system effectively provides the most capacity for a small footprint. The StirCradle stirred tank bioreactor is ideal for research and development involving microorganisms or animal and plant cell cultures.
The StirCradle-PRO is a fully stainless steel fermenter/bioreactor system designed with an automated 5-step cycle SIP system for both culture medium and reactor vessel. Esco VacciXcell offers a wide range of standard reactor capacities from 20 L up to 1,000 L; however, customized reactor sizes are available should users require.
Several training courses are available on-hand to equip customers with proper knowledge and skills to set-up and operate the equipment. Esco VacciXcell also offers advanced courses through webinars that cover topics such as Introduction to Tide Motion, Introduction to Stirred Tank Bioreactors, Speeding Up Your Vaccine Development, and more.
Application courses are also offered such as inoculation/cell culture and sampling techniques, harvesting procedures, and primary product recovery.