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The CradlePro-Iso is an integrated system that combines the Esco Versati™ Centrifuge, Esco CO2 incubator, and CelCradle™ benchtop bioreactor system inside the Esco HPI G3. The CelCradle™ system provides cells with an environment of extremely low shear stress, zero foaming, and of high rates of aeration and nutrition, while the CO2 incubator controls the cells surrounding conditions.

The CradlePro-Iso was designed to fully enclose the cell processing system inside an isolator to ensure the safety of the operator, without compromising the quality of the product.


  • Works under the tide motion principle, wherein cells are exposed intermittently to nutrition and aeration through the compression and decompression of the bellows
  • Each CelCradle™ bottle provides up to 15,000 cm2 of surface area for cell attachment and proliferation
  • Each CelCradle™bottle is capped with a lid that is lined with a 0.22 µm PTFE filter
  • Each CelCradle™bottle can accommodate up to 5 billion cells
  • The system can run in batch, fed-batch, and perfusion modes
  • Each CelCradle™bottle is designed for single use only, eliminating the need for sterilization
  • Provides ISO Class 5 environment in the work chamber
  • Fitted with H14 filters with typical efficiency of 99.995% at 0.1 to 0.3 microns
  • 3 Sets of H14 Filter: 1 for supply and 2 for exhaust
  • Esco Isocide™ antimicrobial coating on all painted surfaces minimizes contamination
  • Ergonomically front-angled and 200 mm gloveports for improved reach and comfort
  • SteriSafe™ ULPA filtration system maintains ISO Class 5 environment inside the incubator
  • Fast CO2, temperature and humidity recovery without overshoot
  • The interior of the chamber is made from stainless steel type 304.
  • Maintenance-free brushless motor
  • Diverse choices of rotors
  • Motor driven lid lock
  • Ensure safety and reliability
  • Adjustable acceleration control system


  • Protein Expression
  • Virus Production
  • Monoclonal Antibody Production
  • Cell Processing
  • Cell Therapy
  • Vaccine Research
  • Small Scale Phase III Vaccine Production


  • Microscope
  • Centrifuge
  • Liquid Transfer System
  • Benchtop Filling Machine
  • Biodecontamination System
  • Glove Leak Tester