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CelCradle X® Closed Automated Single-Use Bioreactor

The Next Cradle Generation for Adherent Culture
CelCradle X® is a single use, closed, and automated bioreactor based on the Tide Motion platform. It is manufactured in an ISO 13485 Esco factory and complies with cGMP requirements of 21 CFR part 11.
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CelCradle X<sup>®</sup>

Tide Motion in CelCradle X®


  • Complete standalone bioreactor running on Siemens HMI/PLC with single-use bottles, pH, and DO sensors
  • Can be used as a standalone bioeactor or integrated with an Esco Laminar Airflow Cabinet, Biosafety Cabinet, or Cell Processing Isolator
  • Equipped with H202 biodecontamination system. Produced in an ISO 9001/14001/13485 factory
  • Automated seeding and control of pH/DO and glucose (optional)
  • Single use automated harvesting system for autologous cell therapy, process development, and seed train for TideXcell™
  • Able to use autoclavable pH/DO sensors for process development and switch in situ for single use pH/DO


  • Vaccine Production
  • Monoclonal Antibodies or Recombinant Proteins for therapeutics/in vitro/in vivo diagnostics
  • Drug Discovery
  • Conditioned media production for cosmeceuticals
  • Adherent cell master cell bank (MCB) or working cell bank (WCB) generation
  • Intracellular, Secreted Viral Vector or Virus Process Development
  • Proteome Research
  • PK/PD Testing
  • Virus MVB production

CelCradle X® External View

CelCradle X® Internal View