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An adequate number of cells is required for inoculation in a particular bioreactor. Starting from cells thawed from bank, cells are then cultivated through a series of cultivating systems and passages. Each passage becomes larger and would require higher volumes of media and other resources. At times, further optimization is needed to replicate the fold increase with each seed train. Esco Healthcare bioreactors are linearly scalable for each seed train, reducing time required for optimization of the process for generating seed train.

Tide Motion Bioreactors

Linearly Scalable bioreactors

From CelXrocker™, CelCradle™ or CelCradle™ X, to TideXcell™, cell seed preparation uses the same principle and parameters. This reduces the bioprocessing time and costs associated with optimization of the seed train for larger scale manufacturing
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Tide Motion Bioreactors

TideXcell™
3,500 up to 5,000 L

Tide 2mm/s: 3,000 - 5,000 L (st. st. tanks)
Tide 6mm/s: 55,000 L

Large st. st. tank,scale for secreted virus production, viral vectors, cellular agriculture (optional edible scaffolds), or biosimilars/biobetters

TideXcell™
300 L

TideXcell™
100 L

TideXcell™
20 L

TideXcell™
2 L

CelCradle ™

with Semi-automated Harvester Esco standalone bioreactor. Single Bottle, Optional Docking to Isolator.

CelCradle™ + CelShaker™

Early stage research and development. One stage can occupy 4 CelCradle bottles, integrated inside client's CO2 incubator. Manual control

CelXrocker™

2D Tide proof of concept (POC) quick data seed ~20,000-60,000 cells per carrier

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