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Roller Bottles to Closed System | Esco VacciXcell

Mass cultivation of cells has become important especially in the production of viral vaccines or for obtaining therapeutic proteins. Roller bottles are two-dimensional (2D) system commonly used for cultivation of adherent cells (anchorage-dependent cells) as it provides the same techniques as with traditional cell culture flasks.

Esco VacciXcell’s Tide Motion bioreactor system is similar to the principle of roller bottle system, as it also alternately exposes the cells to aeration and nutrition. However, the tide motion system overcomes most of the disadvantages associated with the roller bottle system as well as other static cell culture system including space requirement, amount of labor, contamination risk and most importantly production capacity.