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Egg-based Influenza Vaccines | Esco VacciXcell

Egg-based Influenza Vaccines

Production of egg-based vaccines which have been the mainstay of Influenza Vaccine prevention are commonly grown in the allantoic cavity of embryonated hen eggs (EHE). It involves the following processes beginning with the identification of the predicted virus strain. Quadrivalent vaccines, for example, are composed of IAV: H1N1 and H3N2 viruses, and IBV: Yamagata and Victoria viruses. A strain will be selected, and genetic segments will be reassorted into an egg-adapted virus. Once these viruses are generated, they will be injected into the eggs and screened to isolate “candidate vaccine viruses” or CVVs that are able to yield high viral titers and remain antigenic-like the circulating strains. The CVVs will then be mass-produced by vaccine manufacturers using specific pathogen- free (SPF) eggs, allowing them to replicate inside. As a final step in vaccine production, the allantoic fluid of the egg will be purified. The entire workflow is summarized in the photo