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Client Cases Transferring from Roller Bottles to TideXcell™ | Esco VacciXcell

Client Cases Transferring from Roller Bottles to TideXcell™

A(H1N1) Influenza Vaccine
Compared Item Roller bottle TideCell
Performance Analysis
Scale 2 L, 850 cm2 per bottle 10 L
Carrier None 550 g
Max. cell density 1 x 108 1.5 x 1011
Culture days 6 6
Average Virus concentration 128~256 HA 512~1024 HA
Culture medium (cell culture) 200 mL 250L
Virus production days 4 4
Culture medium (virus production) 200 mL 50 L
Equivalency 11,000 1
Cost Analysis (based on the same productivity)
Space 300 m2 3~6 m2
Labor 20~30 2
Culture medium 400 L (~USD 4,000) 300 L (~USD 3,000)
A(H1N1) Influenza Vaccine

TideXcell™-010 replaces 1,000 pieces of roller bottles with higher cell yield. TideXcell™-010 was able to produce a virus concentration of 512-1024 HA compared to 128-256 HA. Labor cost and medium consumption is reduced by more than 50%.

Human H5N1 Vaccine
Compared Item Roller bottle TideCell
Performance Analysis
Scale 15 L, 3000 cm2 per bottle 10 L
Carrier None 550 g
Max. cell density 4~6 x 108 1 x 1011
Culture days 3 3
Culture medium (cell culture) 1.5 L 50 L
Virus production days 16 28
Culture medium (virus production) 6 L 720 L
Equivalency 443 1
Cost Analysis (based on the same productivity)
Space 100 m2 3~6 m2
Labor 10~20 2
Carriers 550 g
Culture medium 2,658 L (~USD 26,580) 720 L (~USD 7,200)
Average Virus concenctaion 40 mil. RID/ml 200 mil. RID/ml
Human H5N1 Vaccine

TideXcell™-010 replaces 443 pieces of roller bottles with higher cell yield. TideXcell™-010 was able to harvest 1x1011 cells compared to 4-6x108 cells in roller bottles. Labor cost and medium consumption is reduced by more than 70%.

Human Hepatitis A Vaccine
Compared Item Roller bottle TideCell
Performance Analysis
Scale 2 L, 850 cm2 per bottle 2 L, 10 L, 20 L
Carrier None 110 g, 1100 g
Max. cell density 1 x 108 2 x 1010, 1 x 1011, 2x1011
Average Virus concentration 1 arbi. unit/bottle 80, 330, 700 arbi. unit/bottle
Culture days N/A N/A
Culture medium (cell culture) 4.2 L 50 L, 250 L, 500 L
Virus production days 21 21
Culture medium (virus production) 4.2 L 50 L, 250 L, 500 L
Equivalency 80, 330, 700 1
Cost Analysis (based on the same productivity)
Space 100 m2 3~6 m2
Labor 10~20 2
Culture medium 2,940 L (~USD 29,400) 500 L (~USD 5,000)
Human Hepatitis A Vaccine

TideXcell™-002, -010, -020 replaces 80, 330, 700 pieces of roller bottles accordingly with higher cell yield. TideXcell™ systems were linearly scalable, yielding 2x1010 , 1x1011 , 2x1011 cells compared to 1x108 cells in roller bottles. Labor cost and medium consumption is reduced by more than 70%.

Hog Cholera Vaccine
Compared Item Roller bottle TideCell
Performance Analysis
Scale 15 L, 3000 cm2 per bottle 10 L
Carrier None 550 g
Max. cell density 4~6 x 108 1 x 1011
Average Virus concentration 40 mil. RID/ml 200 mil. RID/ml
Culture days 3 3
Culture medium (cell culture) 1.5 L 50 L
Virus production days 16 28
Culture medium (virus production) 6 L 720 L
Equivalency 443 1
Cost Analysis (based on the same productivity)
Space 100 m2 3~6 m2
Labor 10~20 2
Carriers 550 g
Culture medium 2,658 L (~USD 26,580) 720 L (~USD 7,200)
Hog Cholera Vaccine

TideXcell™-010 replaces 443 pieces of roller bottles with higher harvested virus concentration. TideXcell™-010 was able to produce a virus concentration 200 mil. RID/ml compared to 40 mil. RID/ml. Labor cost and medium consumption is reduced by more than 50%.