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How They Are Made | Esco VacciXcell

How They Are Made

Secreted growth factors and cytokines play a role in cell division, the growth of new cells, and promote the synthesis of collagen, elastin, and hyaluronic acid. These structural elements are found in the skin which naturally reduces with age and are vulnerable to environmental stressors. Producing these growth factors and cytokines involve the use of a cell line which can proliferate and produce these target products in large amounts.

Mean ratio (3D/2D)
IL-6 IL-8 VEGF
(A) 1.73 ± 0.17* 2.28 ± 0.04*** 1.22 ± 0.54
(B) 4.00 ± 0.23* 1.69 ± 0.05** 1.88 ± 0.36
Average 2.87 ± 1.60 1.98 ± 0.41 1.55 ± 0.47
*, **, *** Significant difference (p < 0.05, 0.01, 0.001) between 2D and 3D BM-MSC cultured in 3D BioNOC™ II carriers displayed upregulated
IL-6 and IL-8 secretion levels compared to 2D cultures.

The principal cells or MSCs utilized for producing facial serum-based ingredients, are adherent cells. Esco VacciXcell provides a solution for high quality production of conditioned medium that can be used in the cosmeceutical industry. BioNOC™ II is a macrocarrier, made from 100% PET that offers a large surface area for MSCs to attach to and proliferate.

The carrier’s configuration is in 3D which allows MSCs to grow in the surface of the fibers and in between the spaces of these fibers as well as on ECM secreted by cells at higher cell confluency. This mimics the in vivo environment and provides greater cell numbers and subsequently, more secreted factors.

The principal cells or MSCs utilized for producing facial serum-based ingredients, are adherent cells. Esco VacciXcell provides a solution for high quality production of conditioned medium that can be used in the cosmeceutical industry.

BioNOC™ II is a macrocarrier, made from 100% PET that offers a large surface area for MSCs to attach to and proliferate. The carrier’s configuration is in 3D which allows MSCs to grow in the surface of the fibers and in between the spaces of these fibers as well as on ECM secreted by cells at higher cell confluency. This mimics the in vivo environment and provides greater cell numbers and subsequently, more secreted factors.