The Skin is the largest organ of the body and one of the most complicated. It plays a vital role in providing an airtight, watertight, and flexible barrier between the outside world and the highly regulated systems within the body. Its functions on thermal regulation, hydration retention and as a first-line defense against infections make it a very important organ of the body.
With this, scientists, have continuously studying diverse sorts of skin stem cells to produce engineered substitutes that can be used in many different applications.
When a large percentage of skin is lost, cultured epithelial sheets are routinely used to make autologous grafts, which are lifesaving especially for patients with extensive burns. Autologous keratinocytes can be isolated and cultured into cohesive sheets of epithelium that can be transplanted into patients with large skin defects.
Esco VacciXcell offers a unique, automated and a user-friendly Bioreactor that mass produces high quality skin patches in vitro. These are embedded with human skin fibroblasts that will serve as regenerative “patch” that reduces the number of healing days and improves the function and appearance of the affected area/s. This bioreactor system provides an automatic preparation of thin sheets of wound dressing material based on collagen. Cell seeding and media exchange is done automatically.