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CelCradle™

Cradle for your Adherent Cells

CelCradle is a bench-top scale bioreactor system that can support high cell density culture. It is a single-use, cost effective packed-bed bioreactor system for adherent scale-up from laboratory scale to production scale. The system fits inside a 6ft3 CO2 incubator (for batch culture) or 8.5ft3 CO2 incubator (for perfusion culture)

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Tide Motion in CelCradle™

Features

  • Fully Stainless Steel - SS 316 L
  • Pre-sterilized, ready-to-use, disposable
  • Extremely low shear stress, foam-free, O2 limitation
  • Large surface area: one CelCradle™ bottle has a specific surface area of up to 15,000 cm2, comparable to 18 - 20 roller bottles
  • Compact design
  • Controlled by Esco Sentinel Gold
  • Capacity to produce hundreds of milligrams to several grams of secreted proteins or monoclonal antibodies per month in four bottles
  • Few parameters for easy optimization
  • Choice of batch, fed-batch, or perfusion culture modes
  • Scalability by directly multiplying number of bottles used
  • Compatible with most serum-free media
  • Specially treated macroporous carriers surface to grow most anchorage-dependent cells and allow easy harvest of whole cells, cell components or secreted proteins

Applications

  • Mammalian and insect cell culture
  • Monoclonal antibody production
  • Drug discovery
  • Gene and cell therapy
  • Protein and virus production
  • Proteome research
  • Pharmacokinetics study

CelCradle System Complete

Simple to operate and virtually cruve same CelCradle unit stage but utilizes CelCradle™ 500 and 500A bottles

CelCradle Continuous System Complete

Same CelCradle unit stage but utilizes CelCradle™ 500P and 500AP for continuous process.

CelCradle™ Stage Technical Specifications

Dimension 264 W x 359 L X 170 H mm (10.4 x 14 x 6.7 inches)
Weight 7.0 kg(15.4 lb)
Power 100~230 VOLTS AC, 50/60 Hz (Input); 12 VOLTS DC (Output_)
Up-Down Rate 0.25 to 2.0 mm/sec.
Step of 1.0 sec or 1.0 min.
Delay Time 0 to 99 min 59 sec
Step of 1.0 sec or 1.0 min.
Driver Motor DC stepping-motor
Environment 20 ~ 42 °C, 0 ~ 90% relative humidity
(in a CO2 incubator)
Mechanical Protection Hi-low Optical Sensor
Transmission Gear set (ration 1:1.2) and belt
Recommended CO2 incubator dimension CelCradle Complete: CCL-170L model:
505 x 535 x 633 mm(19.9" x 21.1" x 24.9") and
CelCradle Continuous SYstem Complete: CCL-240L model:
595 x 640 x 633 mm (23.4" x 25.2" x 24.9")

CelCradle™ Controller Technical Specifications

Dimension 137 L x 226 W x 40 D mm (5.4 x 8.9 x 1.6 inches)
Weight 1.16 kg(2.6 lb)
Power 100-230 VOLTS AC 50/60 Hz (input): 12 VOLTS DC (Output_)
Environment Room temperature (outside CO2 incubator)
Materials Magnetic back plate, to hold the controller to the side of the incubator

CelFeeder™ Controller Technical Specifications

Dimension 230 W x 131 D x 61 H mm, (5.2 x 9.1 x 2.4 inches)
Weight 0.645 kg (1.42 lb)
Power 85~240 Volts AC, 50/60 Hz (input); ~180 mA
Environment Ambient to 45°C, ~95% Relative Humidity
Application/Bottle Item Code Secreted Protein, Viruses Cell Harvest (for non-screted, proteins, viruses or cells) Carrier Harvest (for protein, extraction or reuse of carriers)
CelCradle™ 500 1400001 Best Application Applicable, but not optimal Applicable, but not optimal
CelCradle™ 500A 1400003 Applicable, but not optimal Best application Best application
CelCradle™ 500P 1400004 Best application Applicable, but not optimal Applicable, but not optimal
CelCradle™ 500AP 1400004 Applicable, but not optimal Best application Best application
  • Generation of HEK293T Seed Train Using CelCradle
  • Mesenchymal Stem Cell Culture in CelCradle
  • CelCradle 500
  • CelCradle 500AP
  • CelCradle 500P

VacciXcell has to date sold over 600 CelCradle Single Use Bioreactors and have a growing portfolio of clients. Due to non-disclosure agreements (NDA) only limited information may be provided of our clients.

Some of these clients are:

 

Country Cell Line Virus Strain Cell Density Virus Titer
USA CEF WEE 4 x107 109pfu/ml
Taiwan BHK-21 Pseudorabies 2.35x107 108.8 TCID50/ml
Taiwan HEK-293 Adenovirus 3.5 x107 108pfu/ml
Taiwan SF-9 Baculovirus 6x107 109pfu/ml