Esco Bioprocessing Products
Esco leverages its expertise in life science manufacturing to provide end-to-end solutions for bioprocessing equipment and tools ranging from upstream to downstream applications.
We cater bioprocessing products intended for different stages of the bioprocessing workflow as follows:
Upstream bioprocessing
- Material and Reagent Preparation
- Manipulation
- Cultivation
Downstream bioprocessing
- Isolation
- Purification
- Concentration
Formulation and Filling
- Formulation into final vessel
Bioprocessing Products
Biological Safety Cabinets
Biological safety cabinets (BSC) are primary engineering control devices used for protecting laboratory technicians or operators from biohazards while also providing an aseptic environment for bioprocessing samples and reagents.
Bioreactors and Fermenters
Bioreactors and fermenters are vessels or reactors where cells can be inoculated, cultivated, and infected. The type of bioreactor depends on the specific cells to be cultured and the target product.
Carrier
Micro/macrocarriers significantly increase the surface area for cells to adhere and grow. Macrocarriers should support the efficient oxygenation and waste transfer from cells to medium.
Cell Culture Monitoring
Monitoring cell growth is necessary to ensure that the cells grow as expected and as a process control to continue cell cultivation. Cell culture parameters such as glucose consumption, pH, DO, agitation, and temperature are commonly monitored.
Cell Processing
Cell processing workflows require controlled environments and different equipment which are used more efficiently when integrated into an isolated system or cGMP facility.
Cell Harvesting
Live cells and intracellular (or non-secreted) products can be obtained from bioreactors by cell harvesting procedures aided by special equipment.
Centrifuges
Centrifuges are considered bioprocessing tools used especially for separating cells and/or products from the cell culture media at a specific speed.
CO2 Incubators
CO2 incubators are capable of supplying CO2 (for pH) while maintaining the suitable temperature for cell growth. Mammalian cell culture at a small scale is usually performed in flasks incubated in a CO2 incubator.
Cold Storage
Laboratory refrigerators and freezers are staple bioprocessing equipment necessary to protect samples, reagents, and products used in cell culture, bioprocessing, and final product storage.
Containment System
Bioprocessing tools that are capable of handling high-risk microorganisms are needed to protect operators and products usually in a maximum containment facility classification based on WHO biosafety guidelines.
Culture Media
Culture medium is also considered as a bioprocessing tool that allows the in vitro culture of cells as they provide the nutrients needed for the proliferation and production of the target.
Laboratory Shakers
Laboratory shakers are commonly used bioprocessing equipment for incubation of different types of cells from microbial to mammalian.
Fermenter/Stirred tank Bioreactor
Esco VacciXcell also provides fermenters/stirred tank bioreactors for the culture of microorganisms and suspension cells. These complement the Tide Motion bioreactors for adherent cells to complete the suite of technologies offered to different types of cell culture systems.
Featured Products
CelCradle X®
CelCradle X® is a standalone automated bioreactor that can be used for cell therapy application, process development, and seed train for a larger adherent cell culture scale.
BioNOC™ II Cell
BioNOC™ II is a macrocarrier with a high surface area to volume ratio and allows efficient oxygen and waste transfer.
TideXcell ®
TideXcell® is a pilot-scale bioreactor designed for linearly scalable adherent cell culture and to achieve time, space, and cost reduction.
Filling Line
Filling line equipment completes the bioprocessing workflow after downstream processing to make drug substances and products.
